| 名稱 | ACVR2B Effector Reporter Cell |
| 型號 | CBP74280 |
| 報價 |  |
| 特點 | ACVR2B Effector Reporter Cell |
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聯系人：蔣經理
電話：4008750250
號碼：
手機：18066071954
地址：南京市棲霞區緯地路9號
Email： zhangxiangwen@cobioer.com
電話：4008750250
號碼：
手機：18066071954
地址：南京市棲霞區緯地路9號
Email： zhangxiangwen@cobioer.com
產品展示 / PRODUCTS
- 詳細內容
| I. Background | |
激活素 A（Activin A）是轉化生長因子-β（TGF-β）超家族的重要成員，是一種多能因 子，參與過敏、自身免疫性疾病、癌癥等免疫失調疾病的發生。 | |
| II. Description | |
ACVR2B Effector Reporter Cell 報告基因藥靶模型很好的模擬了體內 ACVR2A 的信號轉導過程，原理見圖 所示。
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| III. Introduction | |
| Expressed gene: | ACVR2B |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+ 200 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Representative Data
Figure 2. ACVR2B Effector Reporter Cell 測序結果 ACVR2A(NM_001616.5): c.409_410insT/ ACVR2A:p.Y137Lfs*76
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Figure 4. Inhibition ofHuman GDF-8 induced Reporter Activity byACVR2 Blocking Ab in ACVR2B Effector Reporter Cell(2C8). Inhibition of Human GDF-11 induced Reporter Activity by ACVR2 Blocking Ab in ACVR2B Effector Reporter Cell(2C8).
Figure 5. Inhibition of Recombinant Human Activin A-induced Reporter Activity by Samples in ACVR2B Effector Reporter Cell (2C8).
